Mucuna Pruriens (Velvet Bean)

Posted by: @triguy

1. Elaborate on the dangers of taking in tooo much dopa bean
2. why & how does nadh aid in negating the side effects

thanx

Unfortunately, I no longer have the link about Mucuna sides (it was a good one). But the deciding factor for me on avoiding to much use is that Mucuna (or something in it) is a precursor for melanin. Since I have already had several moles surgically removed, I want to limit anything that would increase my chances of turning any of my good moles into bad moles.

Posted by: @triguy

1. Elaborate on the dangers of taking in tooo much dopa bean
2. why & how does nadh aid in negating the side effects

thanx

The co-enzyme - NADH - aka nicotinamide adenine dinucleotide - helps to manufacture ATP, and helps to convert tyrosine into dopamine.

Actually, I mentioned combining quercetin with Mucuna extracts. Anyhow, below is an abstract on NADH in case you are interested...

Stabilized NADH (ENADA) improves jet lag-induced cognitive performance deficit

Birkmayer GD, Kay GG, Vurre E.

Labor Birkmayer & MEDINFO GmbH, Wien.
Wien Med Wochenschr. 2002;152(17-18):450-4.

Current remedies for jet lag (phototherapy, melatonin, stimulant, and sedative medications) are limited in efficacy and practicality. The efficacy of a stabilized, sublingual form of reduced nicotinamide adenine dinucleotide (NADH, ENADAlert, Menuco Corp.) as a countermeasure for jet lag was examined. Because NADH increases cellular production of ATP and facilitates dopamine synthesis, it may counteract the effects of jet lag on cognitive functioning and sleepiness. Thirty-five healthy, employed subjects participated in this double-blind, placebo-controlled study. Training and baseline testing were conducted on the West Coast before subjects flew overnight to the East Coast, where they would experience a 3-hour time difference. Upon arrival, individuals were randomly assigned to received either 20 mg of sublingual stabilized NADH (n = 18) or identical placebo tablets (n = 17). All participants completed computer-administered tests (including Cog Screen) to assess changes in cognitive functioning, mood, and sleepiness in the morning and afternoon. Jet lag resulted in increased sleepiness for over half the participants and deterioration of cognitive functioning for approximately one third. The morning following the flight, subjects experienced lapses of attention in addition to disruptions in working memory, divided attention, and visual perceptual speed. Individuals who received NADH performed significantly better on 4 cognitive test measures (P < or = .05) and reported less sleepiness compared with those who received placebo. No adverse effects were observed with NADH treatment. Stabilized NADH significantly reduced jet lag-induced negative cognitive effects and sleepiness, was easily administered, and was found to have no side effects.

"However, combined with NADH/Quercetin, the effects are very noticeable and POTENT - based on years of experimentation...It has shown some promise in narcoleptics and those with other sleep disorders.
I would definitely categorize it as a "cognitive-enhancer" - "

In my post above, I meant the GOOD effects --> were more noticeable when I combined the NADH and Quercetin with the Mucuna Extracts...

Excess Levodopa is potentially dangerous <-- this was my main point. Also combined with countless other supplements/drugs, it can be even more dangerous...The potential is there is what I was saying...

Below are some interesting abstracts dealing with l-dopa containing plants such as Fava and/or Broad beans and their effects on humans...

Infante, M., et al. Outbreak of acute toxic psychosis attributed to Mucuna pruriens. Lancet. 1990 Nov 3;336(8723):1129.

Vered, Y, et al. The influence of Vicia faba (broad bean) seedlings on urinary sodium excretion. Planta Med. 1997 Jun;63(3):237-40.

Khan A., et al. Insulin potentiating factor and chromium content of selected foods and spices. Biol Trace Elem Res. 1990 Mar;24(3):183-8.

Shulman K., et al. Dietary restriction, tyramine, and the use of monoamine oxidase inhibitors. J Clin Psychopharmacol. 1989 Dec;9(6):397-402.