Pyramiding cycles by heavyiron

thanks very informative..

I don't like exceeding 3.5ml per pin myself.

wow couldnt amagine 3.5 im having problems with 3 rite now

wow couldnt amagine 3.5 im having problems with 3 rite now

Glutes can usually take a pretty high volume. I also like medial delts.

I have done 3. never 3.5

Good read, thanks for taken the time to inform us.

great read. i like your thoughts and will be trying the test/tren/dbol cycle. Can prop be subsituted for the test e or do you recommend staying with test e?

Thanks

Awesome! Very informative. Will be trying this out soon

great read. i like your thoughts and will be trying the test/tren/dbol cycle. Can prop be subsituted for the test e or do you recommend staying with test e?

Thanks

Prop is fine brother.

Heavyiron,

This is really interesting stuff, flies in the face of what we thought in the 2000's (that serum SHBG increases, binding to the relevant AAS being used and rendering it inactive at the AR site). Myostatin was just being talked about when I left the boards. Do you have any links (to the 2009 study) or other places you might point me to get "up to speed" on this theory of plateauing (sp)?

Thanks,

Ronn

Heavyiron i want to run test/deca in a similar way as to what you posted (without the dbol) over 12-14 weeks. Original plan was to run test e wk 1-14 @ 750mg/wk and deca wk 1-12 @400-600 depending on how i react to it. How would you alter that to reflect increases in dosage to avoid myostatin slowing gains? Im happy to go to high doses of aas, but maybe not 1750-2250mg/week of test high?

Any advice would be great!

220lb 5'11" 4th cycle 24 years old

Heavyiron,

This is really interesting stuff, flies in the face of what we thought in the 2000's (that serum SHBG increases, binding to the relevant AAS being used and rendering it inactive at the AR site). Myostatin was just being talked about when I left the boards. Do you have any links (to the 2009 study) or other places you might point me to get "up to speed" on this theory of plateauing (sp)?

Thanks,

Ronn
Mol Cell Endocrinol. ( http://anabolicsteroidforums.com/#) 2009 Apr 10;302(1):26-32. Epub 2009 Jan 21.
Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration.

Lakshman KM ( http://anabolicsteroidforums.com/pubmed?term=Lakshman%20KM%5BAuthor%5D&cauthor=true&cauthor_uid=19356623), Bhasin S ( http://anabolicsteroidforums.com/pubmed?term=Bhasin%20S%5BAuthor%5D&cauthor=true&cauthor_uid=19356623), Corcoran C ( http://anabolicsteroidforums.com/pubmed?term=Corcoran%20C%5BAuthor%5D&cauthor=true&cauthor_uid=19356623), Collins-Racie LA ( http://anabolicsteroidforums.com/pubmed?term=Collins-Racie%20LA%5BAuthor%5D&cauthor=true&cauthor_uid=19356623), Tchistiakova L ( http://anabolicsteroidforums.com/pubmed?term=Tchistiakova%20L%5BAuthor%5D&cauthor=true&cauthor_uid=19356623), Forlow SB ( http://anabolicsteroidforums.com/pubmed?term=Forlow%20SB%5BAuthor%5D&cauthor=true&cauthor_uid=19356623), St Ledger K ( http://anabolicsteroidforums.com/pubmed?term=St%20Ledger%20K%5BAuthor%5D&cauthor=true&cauthor_uid=19356623), Burczynski ME ( http://anabolicsteroidforums.com/pubmed?term=Burczynski%20ME%5BAuthor%5D&cauthor=true&cauthor_uid=19356623), Dorner AJ ( http://anabolicsteroidforums.com/pubmed?term=Dorner%20AJ%5BAuthor%5D&cauthor=true&cauthor_uid=19356623), Lavallie ER ( http://anabolicsteroidforums.com/pubmed?term=Lavallie%20ER%5BAuthor%5D&cauthor=true&cauthor_uid=19356623).
Source

Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Boston, MA 02118, United States.

Abstract

Methodological problems, including binding of myostatin to plasma proteins and cross-reactivity of assay reagents with other proteins, have confounded myostatin measurements. Here we describe development of an accurate assay for measuring myostatin concentrations in humans. Monoclonal antibodies that bind to distinct regions of myostatin served as capture and detector antibodies in a sandwich ELISA that used acid treatment to dissociate myostatin from binding proteins. Serum from myostatin-deficient Belgian Blue cattle was used as matrix and recombinant human myostatin as standard. The quantitative range was 0.15-37.50 ng/mL. Intra- and inter-assay CVs in low, mid, and high range were 4.1%, 4.7%, and 7.2%, and 3.9%, 1.6%, and 5.2%, respectively. Myostatin protein was undetectable in sera of Belgian Blue cattle and myostatin knockout mice. Recovery in spiked sera approximated 100%. ActRIIB-Fc or anti-myostatin antibody MYO-029 had no effect on myostatin measurements when assayed at pH 2.5. Myostatin levels were higher in young than older men (mean+/-S.E.M. 8.0+/-0.3 ng/mL vs. 7.0+/-0.4 ng/mL, P=0.03). In men treated with graded doses of testosterone, myostatin levels were significantly higher on day 56 than baseline in both young and older men; changes in myostatin levels were significantly correlated with changes in total and free testosterone in young men. Myostatin levels were not significantly associated with lean body mass in either young or older men. CONCLUSION: Myostatin ELISA has the characteristics of a valid assay: nearly 100% recovery, excellent precision, accuracy, and sufficient sensitivity to enable measurement of myostatin concentrations in men and women.

PMID: 19356623 [PubMed - indexed for MEDLINE]

Heavyiron i want to run test/deca in a similar way as to what you posted (without the dbol) over 12-14 weeks. Original plan was to run test e wk 1-14 @ 750mg/wk and deca wk 1-12 @400-600 depending on how i react to it. How would you alter that to reflect increases in dosage to avoid myostatin slowing gains? Im happy to go to high doses of aas, but maybe not 1750-2250mg/week of test high?

Any advice would be great!

220lb 5'11" 4th cycle 24 years old

At week 7 start increasing the Testosterone dose and peak at 1,500mg T weekly your last couple of weeks. You need to adjust your macro's as you increase dose because you will become a protein synthesis machine.

Thanks very much for the reply.

Do you think this looks good,

Week 1-6 test e 500mg deca 200mg
Week 7-8 test e 750 deca 400
Week 9-10 test e 1000 deca 600
Week 11 test e 1250 deca 600
Week 12 test e 1500 deca 600
Week 13-14 test e 1500

Or do you think its better to hold the test back at 750-1000 until i drop the deca and then bump it to 1500 once the deca is out at week 13 so as to make up for eliminating one compound with the big increase in test the final 2 weeks?

Thanks again! Great to have somewhere i can get great solid and trustworthy advice!

Does this look a bit better?

Wk1-6 test e 500/deca 200
Wk7-9 test e 750/deca 400
Wk10-12 test e 1g/deca 600
Wk13-14 test e 1500

Arimidex 0.5-1mg daily

Hcg 500iu 2x weekly

Was basically my first cycle. Loved it!