I Need To Make Transdermal Test From Injectables Please Help

Posted by: @HRT4health

- I have posted this on another board but thought putting it up here, too, would be a good idea, please read. Also, this has more to do with chemistry, absorption of transdermal compounds etc. So I think the "Advanced" section is more suitable for this than the "Steroid" section.

Respectfully,
Dan

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My father is 62 years old and had extremely low T levels. 2 years ago he was prescribed testosterone creams and benefited a lot from them, they literally changed his life. He came down from 220 to a very healthy looking 182 and works out 5 days a week. 3 days swimming + 2 days lifting at home.

Unfortunately, the insurance will no longer pay for them and we cannot afford to go to a doctor and pay for the doc visit plus the Testosterone Replacement Therapy out of pocket. Also, FYI, he was using testogel right before he lost access to insurance.

However, I do have access to injectable T (enan, cyp, maybe suspension). Can someone please tell me how I can take an injectable and make a transdermal for him? I myself would rather inject the Testosterone but I am not going to mess with needles for him. I am not always around to give him a shot and if he himself tries to do it and something goes wrong we definitely cannot pay the hospital bills. So injections are out of the question.

Please tell me which type of Test I should use to try and make a transdermal (would suspension be best since it is a smaller molecule and can penetrate most easily?) and what else I may need to add to the formula to enhance penetration rate? Also, what absorption rate should I assume?

Any help would be greatly appreciated...

The problem with compounding an oil based preparation is the ratio of concentration when adding it to a TD base. For instance if you were to use PhloGel Ultra it is recommended that you add no more than 10% of an oil. For those who levigate with an oil such as in high concentration testosterone preparations where 200mg/ml of test is desired in the TD. So if you are staring with a test/oil preparation of say 200mg/ml and you an no more than 10% oil to the TD and your goal is to have a 60ml batch.. you can only add 6ml of the test/oil to the TD. This will yield a paltry 20mg/ml final TD. If you can live with that concentration than do it. Also take into account that a Test-Enth'>test e preparation is not 100% test. I don't recall the actual ratio of hormone to ester but it will also reduce the amount of test per ML of your TD. If you take into account that Phlojel Ultra is a lecithin based organogel it has a higher delivery than hydro alcoholic based gels like Androgel and the like. Androgel has a manufacturer stated deliver of ~10%. PhloJel Ultra will deliver more like 40% so you may be able to use this approach for HRT but definitely not bodybuilding type AAS protocols.

Hope this helps.

I am going to move this because I think you will get more/better responses (not that you response wasn't good Triceptor) in the Anabolics section.

Also, I recall Ergoman once posting that he got his HRT hormones free or at very low cost through some program with the drug company...he doesn't post here any more but you might do a search here using his name...

Lastly, with a script, a compounding pharmacy can produce a T cream for your father that he may be able to afford to just purchase outright. I would explain his situation to a pharmacist and see if they have any advice.

Posted by: @Benson

Lastly, with a script, a compounding pharmacy can produce a T cream for your father that he may be able to afford to just purchase outright. I would explain his situation to a pharmacist and see if they have any advice.

The cost of Testosterone is not the issue, the doctor visits are. I will talk to a pharmacy, however. But you are basically saying that the pharmacy will custom make this? If so, do you know what the ingredients and the process would be?

Thanks

Posted by: @HRT4health

The cost of Testosterone is not the issue, the doctor visits are. I will talk to a pharmacy, however. But you are basically saying that the pharmacy will custom make this? If so, do you know what the ingredients and the process would be?

Thanks

I don't know exactly what they would use but a good compounding pharmacy can easily whip up a testosterone cream to whatever spec the doctor prescribes. Ingredients would be testosterone base and some appropriate carrier.

Another route to consider is to get your hands on an aromatase inhibitor which are OTC and fairly cheap. Dr. John panned this approach but it appears to work and might be ideal for your father without insurance.

J Clin Endocrinol Metab. 2004 Mar;89(3):1174-80.
Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels.

Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

As men age, serum testosterone levels decrease, a factor that may contribute to some aspects of age-related physiological deterioration. Although androgen replacement has been shown to have beneficial effects in frankly hypogonadal men, its use in elderly men with borderline hypogonadism is controversial. Furthermore, current testosterone replacement methods have important limitations. We investigated the ability of the orally administered aromatase inhibitor, anastrozole, to increase endogenous testosterone production in 37 elderly men (aged 62-74 yr) with screening serum testosterone levels less than 350 ng/dl. Subjects were randomized in a double-blind fashion to the following 12-wk oral regimens: group 1: Anastrozole 1 mg daily (n = 12); group 2: anastrozole 1 mg twice weekly (n = 11); and group 3: placebo daily (n = 14). Hormone levels, quality of life (MOS Short-Form Health Survey), sexual function (International Index of Erectile Function), benign prostate hyperplasia severity (American Urological Association Symptom Index Score), prostate-specific antigen, and measures of safety were compared among groups. Mean +/- SD bioavailable testosterone increased from 99 +/- 31 to 207 +/- 65 ng/dl in group 1 and from 115 +/- 37 to 178 +/- 55 ng/dl in group 2 (P < 0.001 vs. placebo for both groups and P = 0.054 group 1 vs. group 2). Total testosterone levels increased from 343 +/- 61 to 572 +/- 139 ng/dl in group 1 and from 397 +/- 106 to 520 +/- 91 ng/dl in group 2 (P < 0.001 vs. placebo for both groups and P = 0.012 group 1 vs. group 2). Serum estradiol levels decreased from 26 +/- 8 to 17 +/- 6 pg/ml in group 1 and from 27 +/- 8 to 17 +/- 5 pg/ml in group 2 (P < 0.001 vs. placebo for both groups and P = NS group 1 vs. group 2). Serum LH levels increased from 5.1 +/- 4.8 to 7.9 +/- 6.5 U/liter and from 4.1 +/- 1.6 to 7.2 +/- 2.8 U/liter in groups 1 and 2, respectively (P = 0.007 group 1 vs. placebo, P = 0.003 group 2 vs. placebo, and P = NS group 1 vs. group 2). Scores for hematocrit, MOS Short-Form Health Survey, International Index of Erectile Function, and American Urological Association Symptom Index Score did not change. Serum prostate-specific antigen levels increased in group 2 only (1.7 +/- 1.0 to 2.2 +/- 1.5 ng/ml, P = 0.031, compared with placebo). These data demonstrate that aromatase inhibition increases serum bioavailable and total testosterone levels to the youthful normal range in older men with mild hypogonadism. Serum estradiol levels decrease modestly but remain within the normal male range. The physiological consequences of these changes remain to be determined.

Thank you Benson. These give me a lot to work with. I will be doing my homework based on all this information and post questions here if I have any. This is a very good resource you guys got goin here.